The manual is devoted to trainings on prevention in the sphere of HIV/AIDS, drug abuse and STDs, as well as forming tolerant attitude among teenagers and the youth. The manual reflects main principles and methods of the set up process, evaluation, as well as practical recommendations on conducting trainings on prevention. Besides, basic information and variants of role plays on prevention can be found in the manual, as well as exercises on issues connected to HIV/AIDS, drug abuse and STDs, forming tolerant attitude. This manual will be interested for people working in the sphere of prevention, specialists of governmental and public organizations: teachers, doctors, psychologists, workers of social and youth services, inspectors on working with adolescents, and students colleges and universities.