The development of ARV drugs has been conducted in several directions. One of the directions for the GlaxoSmithKline Company - development of combined drugs that are more convenient in use and at the same time providing high antiretroviral activity. In 1997 in the USA the first combined drug to treat HIV-infection was approved - Combivir, containing two nucleoside reverse transcriptase inhibitors - lamivudine and zidovudine. This leaflet informs about these inhibitors.